GLUCOSYL TRANSFERASE-ACTIVITY AND DIABETIC MICROANGIOPATHY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (3) , 127-131
Abstract
Thickening of the basement membrane [BM] and deposition of collagen-like substances in vascular lesions are well-known findings in diabetes mellitus, suggesting altered metabolism of glycoproteins. Glomerular glucosyltransferase activity were measured in normal and diabetic rats. Enzymic activity in diabetic animals did not differ from control. Another mechanism must be involved in the thickening of the BM, such as increased production of hydroxylysine-rich peptides or decreased breakdown of BM materials.