A DOUBLE-BLIND COMPARISON OF BUPROPION AND AMITRIPTYLINE IN DEPRESSED INPATIENTS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (5) , 115-117
Abstract
Bupropion and amitriptyline were compared in a double-blind study of depressed inpatients. Treatment ranged from 2-4 wk: early responders (Hamilton Depression Scale scores < 10) were often removed from treatment after 2 or 3 wk. Twenty-two patients completed treatment with bupropion and 18 with amitriptyline. Doses ranged from 450 to 750 mg/day for bupropion and 75 to 225 mg/day for amitriptyline. Bupropion and amitriptyline were equally effective as measured by the Hamilton Depression and Anxiety scales, Clinical Global Impressions, Zung Depression scale and the SCL-90 [Symptoms Checklist-90]. Differences in the side effect profile and in weight change are described.

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