Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed ( Astragalus lentiginosus )
- 9 April 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4542) , 190-191
- https://doi.org/10.1126/science.6801763
Abstract
The indolizidine alkaloids swainsonine and swainsonine N-oxide were isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal .alpha.-mannosidase by these alkaloids suggested that they were the causative agents of locoism in range animals.This publication has 12 references indexed in Scilit:
- Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescensBiochemical Journal, 1980
- c. The characterization and thermolysis of cis- and trans-(¦)-laudanosine N-oxideAustralian Journal of Chemistry, 1980
- A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescensAustralian Journal of Chemistry, 1979
- LYSOSOMAL STORAGE IN SWAINSONA SPP. TOXICOSIS: AN INDUCED MANNOSIDOSISNeuropathology and Applied Neurobiology, 1978
- The Occurrence of Nitro-Toxins in North American Astragalus (Fabaceae)Brittonia, 1977
- N-oxides of hyoscyamine and hyoscine in the solanaceaePhytochemistry, 1975
- Chromatographic methods for the isolation of miserotoxin and detection of aliphatic nitro compoundsPhytochemistry, 1974
- Pathology of Locoweed (Astragalus lentiginosus) Poisoning in Sheep; Sequential Development of Cyloplasmie Vacuolation in TissuesPathologia veterinaria, 1970
- Comparative Pathology of Astragalus (Locoweed) and Swainsona Poisoning in SheepPathologia veterinaria, 1970
- Slaframine. Structural Studies of a Parasympathomimetic Alkaloid of Fungal OriginJournal of the American Chemical Society, 1966