Correlations between surface area and the rate of enzymatic desaturation with methyl branched 8,11,14‐eicosatrienoic acid
- 1 September 1979
- Vol. 14 (9) , 826-828
- https://doi.org/10.1007/bf02533524
Abstract
Methyl-branched derivatives of methyl 8,11,14-eicosatrienoate form stable liquid-expanded monolayers. Surface areas are expanded by the methyl branch. The expansion effect is a function of surface pressure. At high surface pressure, the greatest expansion occurs with a mid-point methyl branch. At low surface pressure, surface area increases continuously as the methyl group is moved along the carbon chain from carbon 19 to carbon 5. Desaturase activity varies inversely with surface area, and a linear correlation exists between surface area at low surface pressure and the desaturation rate. These data support the concept that lipid structure and its effect on short range forces between molecules is an important factor in desaturase activity.This publication has 18 references indexed in Scilit:
- The total synthesis and characterization of six methyl branched isomers of 8,11,14-eicosatrienoic acidChemistry and Physics of Lipids, 1976
- MECHANISM OF RAT-LIVER MICROSOMAL STEARYL-COA DESATURASE - STUDIES OF SUBSTRATE-SPECIFICITY, ENZYME-SUBSTRATE INTERACTIONS, AND FUNCTION OF LIPID1976
- Studies on the substrate specificity of the fatty acid 5-desaturase by use of methyl branched isomers of eicosa-8,11,14-trienoic acid and the metabolism of these acids in rat liverArchives of Biochemistry and Biophysics, 1975
- Dynamic properties of fatty acid monomolecular filmsChemistry and Physics of Lipids, 1971
- Specificity of the fatty acid desaturasesArchives of Biochemistry and Biophysics, 1971
- Monomolecular films of mixtures: I. Stearic acid with isostearic acid and with tri-p-cresyl phosphate. Comparison of components with octadecylphosphonic acid and with tri-o-xenyl phosphateJournal of Colloid Science, 1954
- Grenzflächenuntersuchungen an langkettigen polaren Verbindungen im Hinblick auf deren biologisches VerhaltenColloid and Polymer Science, 1952
- Monolayers of Branched-Chain Fatty Acids IBulletin of the Chemical Society of Japan, 1952
- Biochemie verzweigter Carbonsäuren. IV. Mitteilung: Monomolekulare Filme derα-n-Alkyl-stearinsäurenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1950
- Monolayers of compounds with branched hydrocarbon chains. I. Di-substituted acetic acidsTransactions of the Faraday Society, 1940