Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
- 1 June 1999
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 5 (6) , 643-650
- https://doi.org/10.1038/9488
Abstract
Vaccine strategies aimed at blocking virus entry have so far failed to induce protection against heterologous viruses. Thus, the control of viral infection and the block of disease onset may represent a more achievable goal of human immunodeficiency virus (HIV) vaccine strategies. Here we show that vaccination of cynomolgus monkeys with a biologically active HIV-1 Tat protein is safe, elicits a broad (humoral and cellular) specific immune response and reduces infection with the highly pathogenic simian-human immunodeficiency virus (SHIV)-89.6P to undetectable levels, preventing the CD4+ T-cell decrease. These results may provide new opportunities for the development of a vaccine against AIDS.Keywords
This publication has 37 references indexed in Scilit:
- Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNAScience, 1998
- A Genetic and Viral Load Analysis of the Simian Immunodeficiency Virus during the Acute Phase in Macaques Inoculated by the Vaginal RouteAIDS Research and Human Retroviruses, 1998
- Effect of Antibody to HIV-1 Tat Protein on Viral Replication in Vitro and Progression of HIV-1 Disease in VivoJAIDS Journal of Acquired Immune Deficiency Syndromes, 1995
- Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcomaNature, 1994
- Importance of the nef gene for maintenance of high virus loads and for development of AIDSCell, 1991
- A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contactCell, 1990
- Speed of progression to AIDS and degree of antibody response to accessory gene products of HIV‐1Journal of Medical Virology, 1990
- Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1Science, 1989
- Cellular uptake of the tat protein from human immunodeficiency virusCell, 1988
- Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell AnemiaScience, 1985