STUDY OF 17-HYDROXYPROGESTERONE-4-C14IN MAN*

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Abstract
The peripheral metabolism of 17-hydroxyprogesterone-4-C14 was studied in a normal subject and a patient with untreated congenital adrenal hyperplasia, to examine the influence of small and large endogenous production of this hormone on the fate of the tracer. The excretion of radioactivity was slow in both subjects. Pregnane-3[alpha], 17[alpha], 20[alpha]-triol and 3[alpha], 17[alpha]-dihydroxy pregnane-20-one were the major metabolites, whereas their epimers accounted for only a small percentage of the total radioactivity. Formation of androsterone and etiocholanolone occurred to a limited extent; this metabolic transformation in the patient with congenital adrenal hyperplasia was found to be double that in the normal subject.