Activation of the Human Leukocyte Proteinases Elastase and Cathepsin G by Various Surfactants
- 1 January 1990
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 371 (2) , 721-724
- https://doi.org/10.1515/bchm3.1990.371.2.721
Abstract
A systematic study comprising 28 synthetic ionic and nonionic surfactants was carried out in order to examine their effect on the activity of elastase and cathepsin G from human leukocytes against 4-nitroanilide substrates. The whole spectrum, ranging from a complete loss to a pronounced rise in enzymatic activity, was observed at a 0.1% (w/v) surfactant concentration. Most significantly, benzalkonium chloride led to a five-fold increase in elastase activity.This publication has 15 references indexed in Scilit:
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