The metabolism of 4-c14-17[alpha]-hydroxyprogesterone, injected intravenously into 6 endocrinologically normal women (3 with bile fistulas), was essentially like that described previously by other investigators for large quantities of 17[alpha]-hydroxyprogesterone. Differences from reported results were the presence of tetrahydro-cortisone, the absence of significant amounts of androgenic 17-ketosteroids, and the predominance of pregnane-3[alpha],17[alpha]-diol-20-one over pregnanetriol in the urine. The biliary metabolites, reported here for the first time, were similar to those in the urine. The endogenous daily production of 17a-hydroxyprogesterone was calculated to be approximately 2 mg.