Activation of Human Coagulation Factor VIII by Activated Factor X, the Common Product of the Intrinsic and the Extrinsic Pathway of Blood Coagulation

1 August 1982

journal article
research article
Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis

Vol. 47 (02) , 096-100
https://doi.org/10.1055/s-0038-1657137

Abstract

Summary: The intrinsic activation of human factor X has been studied in a system consisting of purified factors and in plasma. In both these systems factor Xa stimulated the activation of factor X by factor IXa plus factor VIII This is due to the activation of factor VIII by factor Xa. When this factor Xa is formed via the extrinsic pathway, the extrinsic factor X activator functions as a stimulator of the intrinsic factor X activator.

Keywords

This publication has 1 reference indexed in Scilit:

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.
Proceedings of the National Academy of Sciences, 1977