Long-term variability in serum thyroglobulin and thyroid related hormones in healthy subjects

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Abstract
From 5 young males and 5 young females blood was drawn under highly standardized conditions on 6-10 occasions during 4 mo. The serum constituents thyroglobulin, thyroxine, triiodothyronine [T3] T3-uptake test, TBG [thyroxine binding globulin] and thyrotropin were determined, and 4 indices were calculated. The biological intra-individual coefficients of variation were below 0.14 for thyroglobulin, and the inter-individual coefficients of variation ranged from 0 for T3-uptake test to 0.35 for thyroglobulin. All results were within the generally accepted reference ranges for normals. Within these ranges the calculations of indices for free thyroxine and T3 according to T3-uptake test and TBG, did not significantly reduce the coefficients of variation for these serum constituents. Thyroglobulin concentrations did not correlate to any of the measured or calculated constituents. The knowledge of these intra- and inter-individual variations of serum thyroglobulin in healthy persons is of importance for the interpretation of variations found in patients.

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