Effects of long‐chain N‐acylethanolamines on lipid peroxidation in cardiac mitochondria
- 12 September 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 237 (1-2) , 49-52
- https://doi.org/10.1016/0014-5793(88)80169-8
Abstract
A long-chain N-acylethanolamine (N-oleoyl-2-aminoethanol) is shown to inhibit the production of thiobarbituric acid-reactive substances in rat heart mitochondria treated with Fe2+ or Fe3+/ADP. The inhibition is concentration-dependent in the range 50–150 μM of the agent and can be nearly complete depending on the type and amount of the free radical-generating system. Structural analogues of N-acylethanolamine are inhibitory as well, but neither oleic acid nor ethanolamine has measurable effects. N-Oleoyl-2-aminoethanol affects peroxidation of linoleic acid micelles only minimally and has no effect on deoxyribose peroxidation.Keywords
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