ASSAY OF COMMERCIAL EXTRACTS OF LIVER FOR PARENTERAL USE IN PERNICIOUS ANEMIA

15 September 1934

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 103 (11) , 802-808
https://doi.org/10.1001/jama.1934.02750370006002

Abstract

Much water has run under the bridge since the report in 1926 by Minot and Murphy¹that a hitherto fatal disease, pernicious anemia, could be effectively treated by the use of large amounts of liver. The preparation of an effective fraction or extract of liver was soon announced by Cohn, Minot and their associates.²Since 1927, various commercial extracts have been available for clinical use. These have been in the form of a simple aqueous concentrate or as the material soluble in 70 per cent but insoluble in 95 per cent alcohol (fraction G of Cohn), prepared as a powder or in water-alcohol solution. Lately this fraction has been prepared in aqueous solution suitable for parenteral administration. The organs of a variety of animals have been used: the cow, the sheep, the pig, the horse, and even the codfish. After the discovery that pernicious anemia was a disorder

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