INHIBITION BY A STABLE ANALOGUE OF ADENOSINE TRIPHOSPHATE OF PLATELET AGGREGATION BY ADENOSINE DIPHOSPHATE

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Abstract
In citrated platelet‐rich plasma, freshly prepared from rabbit blood, the velocity of platelet aggregation was within limits proportional to the log of the concentration of added adenosine diphosphate (ADP). Addition of either adenosine triphosphate (ATP) or its β,γ‐methylene analogue inhibited aggregation similarly except that the analogue was about half as potent as ATP. β,γ‐Methylene ATP also reversed the optical effects associated with the shape change of platelets very similarly to ATP itself. As β,γ‐methylene ATP is not a substrate for nucleoside diphosphokinase, these observations do not support the proposition that inhibition of aggregation by added ATP is due to its utilization by the nucleoside diphosphokinase of platelets.