Ondansetron plus Dexamethasone Compared to the ‘Standard’ Metoclopramide Combination

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Abstract
This paper describes a multicentre, double-blind, parallel group study which compared ondansetron (0.15 mg/kg i.v. X 3) plus dexamethasone (20 mg i.v.) with metoclopramide (3 mg/kg i.v. X 2) plus dexamethasone (20 mg i.v.) and diphenhydramine (50 mg i.v.) for the prevention of cisplatin-induced emesis and nausea. Two hundred and eighty-nine consecutive patients receiving chemotherapy containing cisplatin at doses > 50 mg/m2 entered the study and 267 patients were evaluable for efficacy. The ondansetron regimen was significantly superior compared with the metoclopramide regimen in the control of acute emesis and nausea. Ondansetron plus dexamethasone provided complete protection against retching and vomiting in 79% of patients compared with 59% of patients given the metoclopramide combination (p

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