Die Struktur des Antibioticums Roridin E. Verrucarine und Roridine, 21. Mitteilung [1]

Abstract
Structure 1 has been established for roridin E (C29H38O8), an antibiotic isolated from cultures of Myrothecium species. Base catalysed hydrolysis of 1 gave the known sesquiterpene alcohol verrucarol (4; C15H22O4) and 2′‐anhydrororidinic acid (6; C14H20O6), a new dicarboxylic acid. The structure of 6 was determined by spectral analysis of its dimethyl ester 7, dimethyl hexahydro‐2′‐anhydrororidinate (9), the acetyl derivative 10, and the oxidation product 11.