Susceptibility of Pneumocystis carinii to artemisinin in vitro
Open Access
- 1 June 1991
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 35 (6) , 1225-1227
- https://doi.org/10.1128/aac.35.6.1225
Abstract
The susceptibility of Pneumocystis carinii to artemisinin (qinghaosu) was determined in short-term primary culture. In untreated cultures, trophozoites increased an average of fivefold over 4 days. Inhibition of parasite growth in cultures treated with artemisinin at concentrations as low as 0.5 microM was seen. In contrast, artemisinin concentrations up to 100 microM had no effect on feeder layer cells.Keywords
This publication has 13 references indexed in Scilit:
- Inhibition of growth of Toxoplasma gondii by qinghaosu and derivativesAntimicrobial Agents and Chemotherapy, 1990
- A randomized comparative study of artemisinine (qinghaosu) suppositories and oral quinine in acute falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1990
- Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumoniaAntimicrobial Agents and Chemotherapy, 1990
- In vitro and in vivo studies of the effect of artemether on Schistosoma mansoniAntimicrobial Agents and Chemotherapy, 1989
- In Vitro Studies ofPneumocystis cariniiThe Journal of Protozoology, 1989
- Propagation and Purification of RatPneumocystis cariniiin Short-Term CellThe Journal of Protozoology, 1989
- Clinical study of the treatment of cerebral malaria with artemether (qinghaosu derivative)Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989
- Pneumocystis carinii Pneumonia: DiagnosisThe Journal of Infectious Diseases, 1988
- The chemistry, pharmacology, and clinical applications of qinghaosu (Artemisinin) and its derivativesMedicinal Research Reviews, 1987
- Antimicrobial susceptibility of Pneumocystis carinii in cultureDiagnostic Microbiology and Infectious Disease, 1985