.beta.-Adrenergic blocking agents. 16. 1-(Acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols
- 1 October 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (10) , 1254-1258
- https://doi.org/10.1021/jm00220a006
Abstract
Synthesis of a series of 1-(acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols is described. Compounds were screened as .beta.-adrenergic receptor antagonists in cats, and their partial agonist activity was evaluated in rats depleted of circulating catecholamines. Some compounds have a pharmacological profile similar to atenolol [cardioactive agent]. Their structure-activity relationships are discussed.This publication has 0 references indexed in Scilit: