Loss of mouse chromosomes in somatic cell hybrids between HT-1080 human fibrosarcoma cells and mouse peritioneal macrophages.

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Abstract
Somatic cell hybrids between mouse peritoneal macrophages and HT-1080 human fibrosarcoma cells lose mouse chromosomes and retain the entire complement of human chromosomes. Somatic cell hybrids between cells derived from 2 mouse continuous cell lines and HT-1080 human cells lost human chromosomes preferentially. Loss of mouse chromosomes is not a general property of hybrids between mouse macrophages and transformed human cells. The hybridization of mouse macrophages with cells derived from 5 human fibroblast lines transformed by SV 40 resulted in the production of hybrid clones that preferentially lost human chromosomes.