Response of Peritoneal Cells to Horseradish Peroxidase and Aldehyde-Fixed Erythrocytes in the Mouse

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Abstract
In adult dd-mice, response of peritoneal free cells to horseradish peroxidase (HRP) or glutaraldehyde-fixed erythrocytes was examined by EM. Peritoneal free cells were classified into 3 types: type I, II and III cells. Type I cells were small lymphocytes, type II cells were medium-sized mononuclear cells and type III cells were macrophages. HRP amount taken up was very large in type III cells. The cells contained numerous vacuoles filled with HRP. Type I and II cells also had vesicles containing HRP. The vesicles were fewer in type I cells than in type II. Type III cells rapidly enclosed erythrocytes by thin cytoplasmic flaps and then ingested several erythrocytes. In type III cells, a labryinth of ramifying tubes seen in the peripheral cytoplasm may have served as a reserve of the membrane system for allowing rapid coverage and internalization of large foreign materials. Some type II cells attached to erythrocytes and took them by a varying depth of invagination. Type I cells did not respond to erythrocytes at all. The 3 types of peritoneal cells could be differentiated by response to foreign materials and by cytologic features.

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