The p-Phenylazophenyloxycarbonyl Protecting Group: Selective Deblocking and Oligonucleotide Synthesis Avoiding Acid Steps
- 1 February 1985
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 4 (1) , 153-155
- https://doi.org/10.1080/07328318508077842
Abstract
The p-phenylazophenyloxycarbonyl group is selectively introduced at nucleoside-5′-OH by reaction with the resp. chloroformate and deblocked e.g. by transesterification/β-elimination. With it we designed a reaction cycle for oligonucleotide support synthesis, that avoids acid deprotection.Keywords
This publication has 3 references indexed in Scilit:
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- Dialkylformamldines: depurination resistant N6-protecting group for deoxyadenosineNucleic Acids Research, 1983
- Use of p-nitrophenyl chloroformate in blocking hydroxyl groups in nucleosidesThe Journal of Organic Chemistry, 1967