National Eye Institute Visual Function Questionnaire in the Age-Related Eye Disease Study (AREDS)

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Abstract
THE AGE-RELATED Eye Disease Study (AREDS) is an ongoing multicenter study of the natural history of cataract and age-related macular degeneration(AMD). The study incorporated a randomized clinical trial designed to evaluate the effect of micronutrient supplementation on the incidence and progression of these 2 conditions. The main results of this trial have been published.1,2 A secondary objective of AREDS was to search for clues about the etiology of cataract and AMD and possible strategies for intervention. At the time of enrollment, participants manifested a wide range of ocular findings, varying from no AMD and no lens opacity, to moderately severe lens opacity or advanced unilateral AMD.