Antagonism of Guanethidine by Dexamphetamine and Other Related Sympathomimetic Amines

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Abstract
Dexamphetamine and certain other indirectly acting sympathomimetic amines prevent or reverse the sympathetic nerve blocking action of guanethidine in anaesthetised cats and dogs. Noradrenaline and dopamine do not antagonise the blocking action of guanethidine. These observations are discussed in relation to the mode of action of guanethidine and to a possible clinical significance of these findings.