Effect of Atropine and SC-15396 on Stimulated Gastric Acid Secretion in the Atlantic Cod,Gadus morhua

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Abstract
Gastric acid secretion was measured in swimming codfish surgically equipped with a catheter draining the stomach. Gastric acid secretion was stimulated by histamine (5 or 15 .mu.g/kg .cntdot. h) or by carbachol (5 .mu.g/kg .cntdot. h). Pretreatment with atropine (1 .mu.mol/kg .cntdot. h) completely prevented the acid secretion induced by carbachol, but did not influence the secretion induced by histamine. Atropine had marked effects on the motor functions of the stomach and seriously reduced the volume draining from the stomach. Infusion of phenol red indicated that the decrease in volume was due to a decrease in recovery of ingested water. SC-15396 [2-phenyl-2-(2-pyridyl)-thioacetamide], antigastrin, significantly depressed acid secretion induced by histamine and reduced carbachol-stimulated secretion, although the latter was statistically insignificant. The effects of SC-15396 are discussed with reference to the absence of receptors for gastrin related to gastric acid secretion in the codfish stomach.