THE RESPONSE OF NERVE TO OXYGEN LACK

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Abstract
Resting and action potentials in the sciatic nerve of the grass frog and the bull frog, and the peroneal nerve of the dog were studied by the slow galvanometer under asphyxial conditions and on return to O. Resting potentials were steadily lowered in an asphyxiated region and returned in O. Action potentials first rose and then fell to zero, and on return to O rose rapidly to high values. In asphyxia the Fleischl effect was reduced, the refractory period prolonged and the fibers blocked. The higher the metabolism the faster was the onset of block. The results are interpreted to mean that block is due to an exhaustion of the oxidizable reserve rather than to an accumulation of metabolites.

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