A Comparative Study of Dexchlorpheniramine Maleate Sustained Release Tablets and Budesonide Nasal Spray in Seasonal Allergic Rhinitis

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Abstract
The efficacy and side effects of oral antihistamine and nasal glucocorticoid therapy were compared in seasonal allergic rhinitis. In a double-blind, double-dummy, group-comparative study, 61 adult grass pollen allergic patients were either treated with dexchlorpheniramine maleate sustained release tablets or with budesonide nasal spray. After 1-wk run-in period, treatment was given for 3 wk in the grass pollen season. Patients treated with budesonide showed significantly less nasal blockage than those who received dexchlorpheniramine (P < 0.05), but there was no difference in the number of sneezes and nose blowings. Patients treated with budesonide used a larger quantity of antihistamine-vasoconstrictor eye drops (P < 0.01). Drowsiness occurred in the group that was treated with dexchlorpheniramine, but mainly during the first week of treatment. The side effects caused by the budesonide spray were few and insignificant. The patients'' overall assessment of the treatment favored the glucocorticoid spray (P = 0.06).