PiT: A new allele in the alpha1-antitrypsin system
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 50 (2) , 221-223
- https://doi.org/10.1007/bf00390245
Abstract
In a genetic investigation of the population in Hessen, Germany, we found a family with a new, rare allele in the Pi system (α1-antitrypsin). According to electrophoretic analysis and isoelectric focusing patterns, it is designated PiT. A pedigree study suggests autosomal codominant inheritance. The serum concentration of six heterozygous carriers of this allele (phenotype M1T or M2T) revealed normal α1-antitrypsin levels.Keywords
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