LOCAL ANTIPHLOGISTIC ACTIVITY OF l-PHENYLALANINE AND l-TRYPTOPHANE

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Abstract
The possibility that some amino acids may have anti-inflammatory activity was suggested to us by the observation that certain amino acids maintain life and influence liver glycogen deposition in adrenalectomized rats (Davis, 1958; Leathem, 1958). Both biological activities are properties of adrenal steroids which have anti-phlogistic activity. Oral tryptophane increases the survival time of adrenalectomized animals and retards the fall of liver glycogen (Kotake & Inouye, 1955). Epsilonaminocaproic acid has anti-inflammatory activity (Winters & Nuss, 1966). It was, therefore, attempted to inhibit, by injecting l-phenylalanine and l-tryptophane, the infiltration of white blood cells (WBC) and polymorphonuclear leukocytes (PMN) into an area of local inflammation produced by the intradermal injection of 1% gelatin solution into adrenalectomized rats as described by Holtkamp, Bates, Heming, Poetsch, Lawrence & Buell (1956). This method is a reliable procedure for testing the local antiphlogistic activity of glucocorticosteroids. Adult male Wistar rats (200–-250 g.) were

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