Relationship of the final α-keratin compositions in dyskeratoses to those along the normal keratinization pathway: aetiological and diagnostic significance

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Abstract
The final .alpha.-keratin compositions attained in the outer horny layer of 16 dyskeratoses have been compared with the series of compositions which is produced during normal epidermal differentation. In each case, the abnormal outer horny layer composition corresponded with that of normal basal, spinous, granular or inner horny cells, with, in some cases, the addition of .alpha.-keratins characteristic of hyperproliferating/regenerating keratinocytes. The results have implications for the aetiology of these diseases. In addition, the distinction between the .alpha.-keratin patterns in certain of the conditions was sufficiently clear to allow the use of the technique as a non-invasive aid to diagnosis.