Effect of the Ionophore Monensin on Herpes Simplex Virus Type l-ïnduced Cell Fusion, Glycoprotein Synthesis, and Virion Infectivity
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 20 (1) , 56-60
- https://doi.org/10.1159/000149375
Abstract
The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins.Keywords
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