Effectiveness of Thiocyanate Analog of Vitamin B12 in Pernicious Anemia.

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Abstract
Thiocyanato-cobalamin (thiocyanate analog of vitamin B12) was fully active hematologically in 2 previously untreated patients with pernicious anemia in relapse. Max. reticulocytosis occurred in each subject on the 7th day of treatment. Dosages were the same as have been used with crystalline vit. B12. Studies on urinary P and uric acid, and on serum P and K showed in both patients a prompt decrease in urinary phosphate which occurred before any change in reticulocyte count. In one patient this was accompanied by a drop in serum P and K. Following the initial decrease there was a marked increase in urinary P parallel with the reticulocyte rise. An increase in urinary uric acid-creatinine ratio accompanied reticulocytosis. Similar biochemical changes have been observed by the authors after vitamin B12 in pernicious anemia patients. They were interpreted as being due to increased utilization of phosphate accompanying a profound stimulation of nucleoprotein metabolism.

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