COMPARISON OF GRANULOPOIESIS IN CULTURE FROM BLOOD AND MARROW CELLS OF NONLEUKEMIC INDIVIDUALS AND PATIENTS WITH ACUTE-LEUKEMIA

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 48  (2) , 235-243
Abstract
For individuals without leukemia, a highly significant correlation was observed between the concentration of CFU-C [committed granulopoietic progenitor cells] obtained from the 2 sites. CFU-C in blood had a slower sedimentation velocity than that reported for marrow and were found not to be in the DNA synthetic phase of the cycle using the tritiated thymidine suicide technique. In patients with acute leukemia, no correlation was observed between concentrations of CFU-C in marrow and peripheral blood, regardless of whether the patients were newly diagnosed, in remission or in relapse. Studies of the peripheral blood apparently do not yield the same information in respect to granulopoietic progenitor cells as do studies of the marrow.