EFFECT OF STRUCTURE ON TUMOR SPECIFICITY OF ALICYCLIC ALPHA-AMINO-ACIDS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (8) , 2271-2273
Abstract
The selective affinity of [carboxyl-11C]-1-aminocyclopentanecarboxylic acid (ACPC) for tumor tissue led to a study of the tumor-localizing characteristics of a series of alicyclic .alpha.-amino acid analogs of ACPC. The tissue distributions of [14C]-1-aminocyclopropanecarboxylic acid, 1-aminocyclobutanecarboxylic acid (ACBC), 1-aminocyclohexanecarboxylic acid, 1-amino-2-methylcyclopentanecarboxylic acid and 1-amino-3-methylcyclopentanecarboxylic acid were compared with that of ACPC in Buffalo rats bearing Morris 5123C hepatomas. ACPC and ACBC had significantly higher tumor-to-nontumor concentration ratios than the other 4 amino acids. ACBC had higher tumor-to-nontumor ratios than ACPC, significantly so for muscle, kidney and testis and marginally so for blood. [carboxyl-11C]ACBC may be a better agent than [carboxyl-11C]ACPC for tumor imaging by positron tomography.