Use of 31 P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia
- 1 May 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (5) , 709
- https://doi.org/10.1212/wnl.39.5.709
Abstract
We investigated postasphyxial brain damage with 31P magnetic resonance spectroscopy (MRS) and correlated it with neurologic assessment and standard laboratory evaluation during the first 10 months of life in 1 infant, baby G. We compared these observations to 31P MRS data from 7 healthy term newborns, 1 normal infant examined serially over the first 8.5 months of life, and 5 other term infants following perinatal asphyxia. MRS noninvasively provides biochemical correlates of the evolution of brain damage following perinatal asphyxia and suggests that pH derived from the inorganic phosphate peak may serve as a marker for brain injury.This publication has 9 references indexed in Scilit:
- Alterations in Cerebral Blood Flow and Phosphorylated Metabolites in Piglets during and after Partial IschemiaPediatric Research, 1988
- The use of the chemical shift of the phosphomonoester P‐31 magnetic resonance peak for the determination of intracellular pH in the brains of neonatesNeurology, 1987
- Simultaneous 31P- and 1H-Nuclear Magnetic Resonance Studies of Hypoxia and Ischemia in the Cat BrainJournal of Cerebral Blood Flow & Metabolism, 1987
- Lactate and pH in the Brain: Association and Dissociation in Different Pathophysiological StatesJournal of Neurochemistry, 1987
- IMPAIRED ENERGY METABOLISM IN BRAINS OF NEWBORN INFANTS WITH INCREASED CEREBRAL ECHODENSITIESThe Lancet, 1986
- CEREBRAL ENERGY-METABOLISM STUDIED WITH PHOSPHORUS NMR-SPECTROSCOPY IN NORMAL AND BIRTH-ASPHYXIATED INFANTS1984
- Cerebral metabolic studies in vivo by 31P NMR.Proceedings of the National Academy of Sciences, 1983
- Intracellular pH in the Brain following Transient IschemiaJournal of Cerebral Blood Flow & Metabolism, 1983
- Effect of cerebral extracellular fluid acidity on total and regional cerebral blood flowJournal of Applied Physiology, 1979