Changes in Intestinal Absorption and Plasma Concentration of Various Lipids After Ileal Reimplantation of Bile Duct

Publisher Website
Google Scholar
Abstract
Reimplantation of the common bile duct into the ileum of the rat at a distance of 80–100 cm distal to its initial duodenal site did not significantly alter the intestinal absorption of cholesterol or total lipid. Such reimplantation at 100 cm however did interfere markedly with absorption of cholate. Rats subjected to chronic reimplantation of the bile duct into the ileum at a distance of 80–120 cm from the initial duodenal site exhibited a decreased plasma concentration of both cholesterol and total lipid despite the ingestion of a cholesterol-enriched diet. It is suggested that excess intestinal loss of bile acids may lead to a significant fall in plasma lipids.