Determination of the relative configuration of 5,6,7,8‐tetrahydromethanopterin by two‐dimensional NMR spectroscopy
Open Access
- 17 December 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 314 (3) , 440-444
- https://doi.org/10.1016/0014-5793(92)81522-n
Abstract
The relative configuration of the pterin moiety of 5,6,7,8‐tetrahydromethanopterin 1, a coenzyme isolated from methanogenic archaea, has been determined by two‐dimensional NMR spectroscopy of N 5 N 10‐methenyl‐5,6,7,8‐tetrahydromethanopterin 2 to be rel‐(6R; 7S; 11R). The complete proton resonance assignment of the pterin moiety or N 5 N 10‐methylene‐5,6,7,8‐tetrahydromethanopterin 3 is described including the relative stereospecific assignment of the C(14a) methylene protons.Keywords
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