BACTERIOPHAGE SPECIFIC FOR MYCOBACTERIUM TUBERCULOSIS, VARIETIES HOMINIS AND BOVIS

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Abstract
A phage, designated DS6A, was isolated from soil from a stockyard following enrichment of the soil samples with ATCC no. 607 and H37Rv. Phage DS6A and a variant, DS6B, are lytic for pathogenic human and bovine tubercle bacilli but not for saprophytic or unclassified strains of mycobacteria. More than 300 strains of mycobacteria, including 196 pathogenic strains recently isolated from tuberculosis patients, have been tested with the two DS6 phages. Antiserum has been produced in rabbits and is 95 per cent inhibitory for the phage in 1 100 dilution. Heating at 56[degree]C for sixty minutes inactivated 75 to 80% of the phage. Slightly less than 90% of the phage was inactivated in 10 minutes by a dose of ultraviolet that killed all tubercle bacilli in 5 minutes.

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