HYPOTHYROIDISM IN CHILDHOOD. IV. THE CREATINE AND CHOLESTEROL RESPONSE TO THYROTROPIC HORMONE1

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Abstract
The effect of the inj. of thyrotrophic hormone on the serum cholesterol and the excretion of urine was studied. As shown previously, the increase of creatinuria is the most sensitive indicator of thyroid response in children. Three types of response to thyrotrophic hormone are described: a "positive" response reflected in increased creatinuria with thyrotrophic hormone and also with thyroid; a "negative" response shown by no effect from thyrotrophic hormone but a marked increase in creatine excretion with thyroid; and a "false negative" response in which no increase in creatinuria occurred either with thyrotrophic hormone or with thyroid. 9 hypothyroid children also showed negative responses. Of 17 normal children, 14 gave positive responses and 3 false negatives. Of 9 dwarfs who presented no evidences of hypothyroidism. 6 gave positive responses and 3 false negatives. The possible causes of the "false negative" responses are discussed.