A Short Effective Preparation of Chiral N,3-Dimethyl-5,7-Dioxo-2-Phenylhexahydro-1,4-Oxazepines
- 1 October 1988
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 18 (15) , 1801-1806
- https://doi.org/10.1080/00397918808060935
Abstract
An improved two-stage procedure has been devised for the synthesis in 50% yield of the title compounds from ephedrine or pseudoephedrine enantiomers and dimethyl malonate using cyanuric chloride/pyridine to lactonise the intermediate ∊-hydroxyacids.Keywords
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