Benzylpiperazine derivatives. III. Quantitative structure - cerebral vasodilating activity relationships of 1-benzyl-4-(3-hydroxy-3-phenylpentyl)piperazine derivatives.

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Abstract
Quantitative structure-cerebral vasodilating activity relationships of 1-benzyl-4-(3-hydroxy-3-phenylpropyl)piperazines were examined. The analyses indicate that the potency depends on the number of methoxyl groups on the benzyl moiety, and the local lipophilicity around the asymmetric carbon atom is also of importance. This work reveals that even initial screening data at a single dose can be analyzed quantitatively.