High Performance Liquid Chromatographic Analysis and Dissolution of Dextropropoxyphene Napsylate with other Analgesics in Capsule Formulations

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Abstract
A reversed phase high-performance liquid chromatographic method was developed for simultaneous quantitation of dextropropoxyphene napsylate in three different formulations. The first contains caffeine and aspirin while the others are combinations with acetaminophene. The mobile phase consisted of acetonitrile (30%) in acetate buffer. The assay was carried at 28Onm wavelength. The method is precise and does not require sample manipulation prior to analysis. The applicability of the assay procedure in studying dissolution rate of capsule formulations is described.