Intrarenal Volumes of Distribution and Relative Diffusion Coefficients of Monohydric Alcohols

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Abstract
Indicator dilution outflow patterns in renal venous blood from anesthetized dog kidney were measured for the monohydric alcohols from methanol to hexanol with tritiated water (THO) and T-1824 dye as reference indicators. Also measured were olive-oil-to-water and red-cell-to-plasma partition coefficients. The indicator dilution results were: (1) at normal hematocrit, the mean transit times of all the alcohols were approximately the same as for THO; (2) at low hematocrit, the mean transit time of hexanol was approximately 1.6 times that of THO; (3) at both normal and low hematocrits, the upslope portion of the alcohol curves was earlier and steeper dian that of the THO curve, the more so with increasing alcohol carbon number. Results 1 and 2 and the partition coefficients were consistent with an increased volume of distribution of hexanol relative to THO, due to the lipid content of kidney cortical tissue. The previously reported convection-diffusion model applied to result 3 provided diffusion coefficients of the alcohols relative to THO in kidney cortical tissue in vivo.