THE INHIBITION OF RAUSCHER LEUKEMIA VIRUS AND AVIAN MYELOBLASTOSIS VIRUS DNA POLYMERASES BY ANTHRACYCLINE COMPOUNDS
- 1 May 1977
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 284 (1) , 566-575
- https://doi.org/10.1111/j.1749-6632.1977.tb21988.x
Abstract
Studies by other investigators have shown that adriamycin and daunorubicin exhibit antitumor and antiviral activity. A possible antiviral mechanism for the anthracycline compounds is the potent inhibition of viral DNA polymerases. Five anthracycline compounds were tested against purified Rauscher leukemia virus and avian myeloblastosis virus DNA polymerases. All compounds were found to be potent inhibitors of viral DNA polymerase activity. Inhibition was found to be primarily due to the planar ring structure (daunomycinone) common to all of these compounds. The degree of inhibition was dependent on the templates used: activated DNA, synthetic hybrids, poly(rA).dT12-18 and poly(rC).dG12-18, and the synthetic copolymer, poly(DA-dT). Alteration of the group substituent on the planar ring affected the degree of viral DNA polymerase inhibition. The inhibitory effects by anthracycline compounds appear to be relatively specific for viral polymerases.Keywords
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