pH regulation of penicillin production in Aspergillus nidulans
- 15 January 1991
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 77 (2-3) , 209-212
- https://doi.org/10.1016/0378-1097(91)90553-m
Abstract
As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pac C which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the pal A, pal B, pal C, pal E or pal F genes which mimic the effects at growth at acid pH.Keywords
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