Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Trial
- 1 June 2008
- journal article
- gastrointestinal cancer
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 26 (16) , 2690-2698
- https://doi.org/10.1200/jco.2007.15.5580
Abstract
Purpose Candidate predictive biomarkers for irinotecan and oxaliplatin were assessed in 1,628 patients in Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS), a large randomized trial of ...Keywords
This publication has 35 references indexed in Scilit:
- Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trialThe Lancet, 2007
- REporting recommendations for tumour MARKer prognostic studies (REMARK)British Journal of Cancer, 2005
- P53 abnormalities and outcomes in colorectal cancer: a systematic reviewBritish Journal of Cancer, 2005
- Is there a case for routine clinical application of ploidy measurements in gastrointestinal tumours?Histopathology, 2004
- Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancerBritish Journal of Cancer, 2003
- Phase II study of irinotecan with bolus and high dose infusional 5-FU and folinic acid (modified de Gramont) for first or second line treatment of advanced or metastatic colorectal cancerBritish Journal of Cancer, 2002
- DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular studyPublished by Elsevier ,2002
- A ‘modified de Gramont’ regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancerBritish Journal of Cancer, 2002
- Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal CancerJournal of Clinical Oncology, 2000
- Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trialPublished by Elsevier ,2000