Long-chain neutral glycolipids and gangliosides of murine fibroblast lines and their low- and high-tumourigenic hybrids.

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Abstract
The patterns of long-chain neutral glycolipids and gangliosides of established, L-cell-derived murine fibroblast lines and their low- and high-tumorigenic hybrids were studied. The presence of long-chain neutral glycolipids was demonstrated by a new procedure, without which they would have been overlooked due to the masking effect of ganglioside on TLC. Results indicate that the highly tumorigenic L cell sublines were characterized by the absence or decrease of the long-chain neutral glycolipids, highly complex ganglioside and/or hematoside, compared to the low-tumorigenic parent cells. Low-tumorigenic hybrids, derived from the fusion of low- and high-tumorigenic cells, acquired long-chain neutral glycolipids and/or complex gangliosides. These components could still be present in high tumorigenic, chromosome loss segregants isolated from some of the low-tumorigenic hybrids by mouse passage, but these segregants were characterized by a decrease or loss of the hematoside.

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