Chemical Protection against Repeated Supralethal Doses of Ionizing Radiation in Mice

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Abstract
When a mixture of 3 radiopro-tective chemicals (2 [mu]M of serotonin, 7 [mu]M of AET, and 25 [mu]M of MEA) was given to mice intraperitoneally 10 minutes before a first radiation exposure of 800 r, 1100 r, or 1400 r, 95%, 92%, and 50% of the animals, respectively, remained alive. On the 36th day after the first radiation exposure, the surviving mice were given the same chemical mixture and the same radiation exposure of 800 r, 1100 r, or 1400 r. It was found that 79%, 93%, and 77% of these animals, respectively, survived the second radiation exposure. In spite of a 9% toxicity due to the administration of 2 doses of the chemical mixture, the total mortalities (combined radiation and drug mortalities) were 14.3%, 22.8%, or 67.2% for those groups of mice receiving two equal doses of 800 r, 1100 r, or 1400 r, respectively. A high degree of chemical protection against repeated supralethal doses of X-irradiation in mice can be achieved when an interval is allowed for tissue recovery between the 2 irradiation.

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