A case report of T-Cell lymphoma with suppressor phenotype and helper function for immunoglobulin synthesis

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Abstract
A patient with T‐cell lymphoma is presented. The morphologic features of a biopsied lymph node were consistent with adult T‐cell lymphoma with hypergammaglobulinemia, and most of the lymph node cells were reactive with monoclonal antibody OKT8, which detects suppressor/cytotoxic T lymphocytes. However, in a pokeweed mitogen‐driven test system in which the capability of T lymphocytes to help or suppress the differentiation of B lymphocytes is measured, the lymphoma cells induced immunoglobulin synthesis of B lymphocytes, thus providing helper function. As far as we know, this is the first report on T‐cell lymphoma having suppressor phenotype and helper function for immunoglobulin synthesis.