Fetal Liver Transplantation in Aplastic Anemia

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Abstract
Fetal liver transplantation was attempted in 7 patients with aplastic anemia. Of these patients, 4 showed partial response as evidenced by decrease in blood transfusion requirements and increase in peripheral blood counts and hematopoietic cells in the bone marrow. Bone marrow culture studies revealed evidence of a temporary mixed lymphoid chimerism (cases 1 and 3). While case 1 lived for 16 mo., case 3 was surviving at 17 mo. No patients showed apparent graft vs. host disease. Increased incidence of infections was noticed. Possible causes for these were discussed. Three patients failed to respond. Fetal liver transplant may be of therapeutic value in management of aplastic anemia.