Fetal and Maternal Virilization Associated With Pregnancy

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Abstract
• A masculinized female infant was born to a mother who had virilizing signs dating from the fourth month of pregnancy. Serum 17 α-hydroxyprogesterone, dehydroepiandrosterone, and testosterone levels were all normal in the infant. Maternal testosterone level was markedly elevated one week post partum. Dexamethasone phosphate suppression was normal. Human chorionic gonadotropin stimulation five weeks post partum revealed further elevation of high baseline free and total testosterone levels. Free and total testosterone levels 30 weeks post partum were normal, and all maternal virilizing signs had regressed with the exception of her deepened voice. The child has had no progression of masculinization. The mother is believed to have had a luteoma of pregnancy. (Am J Dis Child 1982;136:353-356)

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