A Cross-Sectional Comparison of Persons with Syncytium- and Non-Syncytium-Inducing Human Immunodeficiency Virus
- 1 December 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 168 (6) , 1374-1379
- https://doi.org/10.1093/infdis/168.6.1374
Abstract
The association between isolation of the syncytium-inducing(SI) phenotype of human immunodeficiency virus (HIV) and unfavorable clinical and immune status was evaluated in a crosssectional study. Data on HIV phenotype were available for 341 of 878 persons entering clinical trials of antiretroviral therapies. Patients with SI virus were demographically similar to those with non-SI (NSI) virus but weremore likely to havea diagnosis of AIDS and detectable circulating HIV p24 antigen. Patients with SI virus also had a lower CD4+ cell count and a higher serum level of β2-microglobulin. The association between phenotype and present status was explained statistically by CD4+ cell count. Phenotype, serum level of β2-microglobulin, and the presence of detectable p24 antigen were all independent predictors of present CD4+ cell count. The likelihood of finding SI virus increased with unfavorable virologic and immunologic parameters and varied with the amount of prior antiretroviral therapy.Keywords
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